Stronger Cows. Healthier Herds. More Profit.
Backed by over 25 years of research at the University of Guelph, Immunity Technology is a world-leading genetic solution that helps you breed cows with naturally stronger immune systems.

  • Healthier cows with fewer cases of mastitis, metritis, and respiratory disease
  • Lower vet and treatment costs
  • Improved fertility and longevity, keeping cows in your herd longer
  • More profit, with gains that build every generation
    By monitoring immunity in your herd, you’re not just treating disease — you’re preventing it.

  • KETOSIS

    Immunity+® & Ketosis
    Ketosis is one of the most common and costly metabolic diseases in dairy cows, especially in the first few weeks after calving. It occurs when energy demand exceeds intake, leading to excessive fat mobilization and ketone production.

    Estimated Cost of Ketosis/Case:
    Clinical Ketosis: $250–$400
    Subclinical Ketosis: $75–$150

    Most ketosis cases are subclinical, which means they’re harder to detect but still reduce performance.

    How Immunity+ Helps Fight Ketosis
    • Fewer Transition Diseases = Lower Ketosis Risk
      • Ketosis is often triggered or worsened by:
        • Metritis
        • Mastitis
        • Retained placenta
      • HIR cows have lower rates of these diseases, reducing the metabolic and inflammatory stress that contributes to ketosis.
    • Better Inflammatory Control = Improved Liver Function
      • The liver is central to managing energy metabolism.
      • Inflammation from poor Immunity+ can impair liver function, reducing its ability to:
        • Convert fat to usable energy (glucose)
        • Clear ketones from the blood
      • Immunity+ cows show more controlled immune and inflammatory responses, leading to healthier liver function and lower ketone buildup.
    • Stronger Appetite and Rumen Function
      • HIR cows tend to:
        • Eat better after calving
        • Maintain better dry matter intake (DMI)
        • Experience fewer disruptions in rumen function
      • This helps reduce the energy gap after calving — the primary driver of ketosis.
    • Heritable Improvement for Long-Term Resilience
      • Immunity+ is a heritable trait — daughters of Immunity+ sires are more resilient to transition cow diseases and metabolic stress.
      • This leads to cumulative improvement in ketosis resistance across generations.

    FIND OUT MORE
  • Immune Classification And Colostral Quality

  • Genetic Selection Of Cattle For Improved Immunity And Health

  • Variation Of Lactoferrin And Total Immunoglobulin G Concentrations In Colostrum From Canadian Holstein Dairy Cattle Classified As High, Average Or Low Immune Responders

  • Genetic And Epigenetic Regulation Of The Bovine Immune System: Practical Implications Of The High Immune Response Technology

  • Genetic Regulation Of The Bovine Immune System And The Practical Application Of The High Immune Response Technology In Dairy Health Management

  • A Genome-wide Association Study Of Immune Response In Holstein Bulls

  • Genetic And Epigenetic Effects On Bovine Immune Responses And Their Implications To Dairy Health

  • Genetic Selection Of Cattle For Improved Immunity And Health

  • The 3000 Cow High Immune Response (HIR) Genomics Project

  • Prevalence Of Digital Dermatitis In Canadian Dairy Cattle Classified As High, Average Of Low Antibody And Cell-Mediated Immune Responders

  • Variation Of Total Immunoglobulin G And β-Lactoglobulin Concentrations In Colostrum And Milk From Canadian Holsteins Classified As High, Average, Or Low Immune Responders

  • High Immune Response Sires Reduce Disease Incidence In North American Large Commercial Dairy Populations

  • Variation In Production Parameters Among Canadian Holstein Cows Classified As High, Average, And Low Immune Responders

  • Association Of Disease Incidence And Adaptive Immune Response In Holstein Dairy Cows

  • Genetic Parameters Of Adaptive Immune Response Traits In Canadian Holsteins

  • A Genome-wide Association Study Of Immune Response Traits In Canadian Holstein Cattle


  • DISEASES
    BIRD FLU – H5N1
    BOVINE LEUKOSIS
    BOVINE TUBERCULOSIS
    CALF DIARRHEA/SCOURS
    DIGITAL DERMATITIS
    DISPLACED ABOMASUM
    ENDOMETRITIS/METRITIS
    INTERDIGITAL HYPERPLASIA
    JOHNE'S DISEASE
    KETOSIS
    MASTITIS
    PNEUMONIA
    RETAINED PLACENTA

    IMMUNITY TECHNOLOGY
    Only from Semex Elevate® and Neogen®